解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.719953
更新日期:2012-12-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.697594
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.677078
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.664668
更新日期:2012-06-01 00:00:00
abstract::The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.593600
更新日期:2012-03-01 00:00:00
abstract::Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patie...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2011.606450
更新日期:2012-02-01 00:00:00
abstract::The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2011.606444
更新日期:2012-02-01 00:00:00
abstract::We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.579927
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.561818
更新日期:2011-09-01 00:00:00
abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...
journal_title:Autoimmunity
pub_type:
doi:10.3109/08916934.2010.523239
更新日期:2011-06-01 00:00:00
abstract::The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by c...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523275
更新日期:2011-06-01 00:00:00
abstract:MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523272
更新日期:2011-06-01 00:00:00
abstract::Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2010.523260
更新日期:2011-06-01 00:00:00
abstract::T helper type 17 (Th17) cells, a newly identified effector T-cell subset, have recently been shown to play a role in numerous autoimmune diseases, including iodine-induced autoimmune thyroiditis in non-obese diabetic (NOD)-H2(h4) mice, which had previously been thought Th1-dominant. We here studied the role of Th17 in...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916931003777247
更新日期:2011-03-01 00:00:00
abstract::Invariant natural killer T (iNKT) cells represent an important regulatory T-cell subset that perceives signals of danger and/or cellular distress and modulate the adaptive immune response accordingly. In the presence of pathogens, iNKT cells acquire an adjuvant function that is fundamental to boost anti-microbial and ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003782130
更新日期:2011-02-01 00:00:00
abstract::Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903540432
更新日期:2010-12-01 00:00:00
abstract::Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674733
更新日期:2010-11-01 00:00:00
abstract::There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674766
更新日期:2010-11-01 00:00:00
abstract::T and B lymphocytes are central regulators and effectors of immune responses and are believed to have a key role in many autoimmune diseases. Targeting the activation or effector function of lymphocytes is a potentially effective approach to treat autoimmunity. Typically, T-cell activation occurs after engagement of t...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674741
更新日期:2010-11-01 00:00:00
abstract::Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903563491
更新日期:2010-08-01 00:00:00
abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903518107
更新日期:2010-08-01 00:00:00
abstract::Interleukin (IL)-15 and CD30 may be associated with the ongoing intestinal immunologic activation in celiac disease (CD). We studied duodenal biopsies and blood samples of patients with active CD (Cel) and controls in order to determine the regulatory role proposed for CD30(+) T cells in this Th1-driven disease and th...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903405867
更新日期:2010-06-01 00:00:00
abstract::Toll-like receptors (TLRs) are evolutionary conserved molecules that recognize various microbial components and host-derived agonists from damaged cells and play a central role in innate and adaptive immunity. It has been reported that MyD88, the adaptor molecule downstream of all TLRs, except TLR3, is essential for i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903509056
更新日期:2010-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...
journal_title:Autoimmunity
pub_type: 社论
doi:10.3109/08916930903374741
更新日期:2010-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002479
更新日期:2009-11-01 00:00:00
abstract::The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002529
更新日期:2009-11-01 00:00:00
abstract::Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802613210
更新日期:2009-08-01 00:00:00
abstract::CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930902827926
更新日期:2009-05-01 00:00:00
abstract::Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828254
更新日期:2009-05-01 00:00:00
abstract::During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828049
更新日期:2009-05-01 00:00:00
abstract::TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameter...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902831977
更新日期:2009-05-01 00:00:00
abstract::Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902832652
更新日期:2009-05-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802668594
更新日期:2009-03-01 00:00:00
abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802375729
更新日期:2009-02-01 00:00:00
abstract::Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903213993
更新日期:2009-01-01 00:00:00
abstract::The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802282651
更新日期:2009-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is the result of the autoimmune response against pancreatic insulin producing beta cells. This autoimmune response begins months or even years before the first presentation of signs and symptoms of hyperglycemia and at the time of clinical diagnosis near 30% of beta-cell mass still rema...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802200208
更新日期:2008-12-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant au...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802197677
更新日期:2008-12-01 00:00:00
abstract::Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen in animal models of myocarditis and is released from the heart during viral myocarditis, the characterization, role and sig...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802031579
更新日期:2008-09-01 00:00:00
abstract::Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930801890280
更新日期:2008-08-01 00:00:00